Motif ID: HOX{A4,D4}.p2

Z-value: 1.095

Transcription factors associated with HOX{A4,D4}.p2:

NameEntrezDescription
Hoxa4 15401 homeobox A4
Hoxd4 15436 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Hoxa4chr6_-_52141697-0.281.0e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr17_+_80706746 9.303 NM_001145452
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr12_+_30219982 6.385 Myt1l
myelin transcription factor 1-like
chr11_+_56825307 5.539 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr8_-_87461251 5.203 NM_019945
Mast1
microtubule associated serine/threonine kinase 1
chr7_-_20284370 5.068 Apoe
apolipoprotein E
chr7_+_152024499 4.670 NM_008007
Fgf3
fibroblast growth factor 3
chr4_+_97248556 4.633 NM_001122952
Nfia
D130039L10Rik
nuclear factor I/A
RIKEN cDNA D130039L10 gene
chr8_+_115093942 4.305 NM_130457
Cntnap4
contactin associated protein-like 4
chr10_-_63552994 4.286 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chrM_+_3913 4.247


chr11_-_30168153 4.041 Spnb2
spectrin beta 2
chrM_+_3320 3.911


chrM_+_15355 3.880


chr12_+_110783593 3.811 Meg3
maternally expressed 3
chr2_+_138104219 3.627 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr2_-_6805937 3.611 NM_001110228
NM_001160293
NM_010160
Celf2


CUGBP, Elav-like family member 2


chr2_+_70312979 3.572 NM_022435
Sp5
trans-acting transcription factor 5
chr16_+_96689322 3.540


chr11_+_56825258 3.362 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr2_+_61884596 3.321 NM_033552
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chrM_+_12383 3.319


chr6_+_77192615 3.235 NM_028880
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chrX_-_161765324 3.200 Glra2
glycine receptor, alpha 2 subunit
chr18_-_32109233 3.083 NM_001025381
Gpr17
G protein-coupled receptor 17
chr8_-_3625251 3.079 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chr19_-_57271875 3.016 NM_001103177
Ablim1
actin-binding LIM protein 1
chr7_+_86418127 2.969 NM_018811
Abhd2
abhydrolase domain containing 2
chr13_+_58909168 2.918 NM_001025074
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr9_-_91255831 2.836 Zic1
zinc finger protein of the cerebellum 1
chr12_+_30213224 2.834 NM_001093775
NM_001093778
NM_008666
Myt1l


myelin transcription factor 1-like


chr10_+_101621491 2.830 NM_001162368
Mgat4c
4930402I19Rik
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
RIKEN cDNA 4930402I19 gene
chr8_-_87461220 2.671 Mast1
microtubule associated serine/threonine kinase 1
chr13_+_58909236 2.662 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr4_+_144482979 2.648 NM_011303
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr14_+_61757271 2.608 NM_172809
Sacs
sacsin
chr7_+_86418082 2.484 Abhd2
abhydrolase domain containing 2
chr15_+_4325490 2.453 NM_177355
Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chrM_+_3844 2.419


chrM_+_11027 2.389


chrX_-_35605544 2.313 Fam70a
family with sequence similarity 70, member A
chr18_-_31476721 2.309 NM_009065
Rit2
Ras-like without CAAX 2
chr4_+_101180580 2.240 NM_001164584
NM_001164585
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr4_+_109015660 2.206 NM_001159964
Eps15
epidermal growth factor receptor pathway substrate 15
chr10_-_24919916 2.172 Akap7
A kinase (PRKA) anchor protein 7
chr12_+_110784600 2.141 Meg3
maternally expressed 3
chr5_+_137506122 2.113 NM_001039385
Vgf
VGF nerve growth factor inducible
chr2_-_25325248 2.112 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr3_-_80606500 2.083 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr4_+_101180625 2.060 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr1_-_160286359 2.010 NM_207583
Fam5b
family with sequence similarity 5, member B
chr14_+_66963139 1.999 NM_019675
Stmn4
stathmin-like 4
chr15_-_48623520 1.987 NM_001081391
Csmd3
CUB and Sushi multiple domains 3
chr1_+_111880313 1.896 NM_172853
Cdh7
cadherin 7, type 2
chrM_+_2750 1.880


chr4_-_86876311 1.855 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr4_+_119486921 1.854 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr10_+_69487700 1.845 Ank3
ankyrin 3, epithelial
chr18_+_37467108 1.844 NM_053129
Pcdhb4
protocadherin beta 4
chr18_+_37607310 1.839 NM_053139
Pcdhb14
protocadherin beta 14
chr9_-_60535274 1.813 NM_001146047
Lrrc49
leucine rich repeat containing 49
chr2_+_55288297 1.788 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chrX_-_7709907 1.745 NM_026137
Wdr13
WD repeat domain 13
chr19_-_5802596 1.737 Ramp2
Malat1
receptor (calcitonin) activity modifying protein 2
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr10_-_101953046 1.709 NM_024435
Nts
neurotensin
chr15_-_56526052 1.683 NM_008216
Has2
hyaluronan synthase 2
chr11_-_42134548 1.663 NM_001099641
NM_008068
Gabra6

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6

chr3_+_136598184 1.659 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr9_-_49607164 1.623 NM_001081445
NM_001113204
NM_010875
Ncam1


neural cell adhesion molecule 1


chr2_+_90725895 1.605 NM_026161
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr17_-_43803963 1.604 NM_028711
Slc25a27
solute carrier family 25, member 27
chr7_+_139158135 1.603 NM_173410
Gpr26
G protein-coupled receptor 26
chr4_-_86876328 1.580 NM_172426
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr2_-_60801248 1.563 NM_020296
Rbms1
RNA binding motif, single stranded interacting protein 1
chr9_-_30957394 1.558


chr5_+_33361479 1.529 Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr1_-_42724504 1.514 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr3_-_80606598 1.507 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr4_+_138012860 1.502 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr16_-_42340613 1.502 NM_008083
Gap43
growth associated protein 43
chrM_+_1550 1.502


chr5_-_121459496 1.491 NM_011286
Rph3a
rabphilin 3A
chr11_-_79317471 1.471 Omg
oligodendrocyte myelin glycoprotein
chr14_-_65035722 1.461 Msra
methionine sulfoxide reductase A
chrX_-_131285919 1.453 NM_001007578
Armcx6
armadillo repeat containing, X-linked 6
chr2_+_65458814 1.448


chr6_+_104443037 1.446 NM_017383
Cntn6
contactin 6
chr11_+_29607599 1.446 Rtn4
reticulon 4
chr8_-_3624988 1.426 NM_001129804
Pcp2
Purkinje cell protein 2 (L7)
chr11_+_56825192 1.384 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr6_+_88674697 1.365 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr2_-_66248146 1.339


chr10_-_88067758 1.336 NM_175418
Mybpc1
myosin binding protein C, slow-type
chrM_+_14143 1.323


chr9_+_37175190 1.314 NM_175189
Hepacam
hepatocyte cell adhesion molecule
chr11_-_30168142 1.303 Spnb2
spectrin beta 2
chrM_+_409 1.300


chr16_-_37384915 1.290 Stxbp5l
syntaxin binding protein 5-like
chr5_+_107926763 1.286 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr13_+_46597271 1.282 NM_026056
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr18_-_31476626 1.269 Rit2
Ras-like without CAAX 2
chr12_+_30219769 1.266 NM_001093776
Myt1l
myelin transcription factor 1-like
chr8_+_48072271 1.266 NM_177304
Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr18_-_35374663 1.258 NM_178005
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr12_+_109843975 1.235 NM_001163395
Evl
Ena-vasodilator stimulated phosphoprotein
chr2_+_163843294 1.231 Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr2_+_37372112 1.230 NM_177383
Gpr21
G protein-coupled receptor 21
chrX_-_20527674 1.225 NM_007922
Elk1
ELK1, member of ETS oncogene family
chr4_+_119487105 1.194 NM_010657
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr19_+_12040311 1.193 NM_001033174
Osbp
oxysterol binding protein
chr18_+_37649118 1.191 NM_053143
Pcdhb18
protocadherin beta 18
chr6_+_134932018 1.183 NM_001109914
Apold1
apolipoprotein L domain containing 1
chr9_-_91260619 1.180 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr19_-_5085487 1.165 Tmem151a
transmembrane protein 151A
chr8_+_116729508 1.143 NM_173016
Vat1l
vesicle amine transport protein 1 homolog-like (T. californica)
chr18_+_37834003 1.131 Pcdhga3
protocadherin gamma subfamily A, 3
chr17_+_24607348 1.130 NM_025954
Pgp
phosphoglycolate phosphatase
chr18_-_31606908 1.123 NM_009308
Syt4
synaptotagmin IV
chr9_-_121404750 1.122 Cck
cholecystokinin
chr8_+_119984482 1.083 4933407C03Rik
RIKEN cDNA 4933407C03 gene
chr16_+_49911557 1.079 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr3_-_80606641 1.078 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr11_-_42134509 1.057 Gabra6
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
chr19_+_27291507 1.054 NM_001161420
NM_013703
Vldlr

very low density lipoprotein receptor

chrX_-_161764912 1.054 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chrX_+_166123130 1.050 NM_010797
Mid1
midline 1
chrX_+_35954355 1.050 Mcts1
malignant T cell amplified sequence 1
chr1_+_180459245 1.045 NM_001161665
Kif26b
kinesin family member 26B
chr15_-_37389073 1.040 NM_001170867
NM_001170868
Ncald

neurocalcin delta

chr14_-_37911383 1.022 NM_130878
Cdhr1
cadherin-related family member 1
chr9_-_100386803 1.005 NM_001033543
Il20rb
interleukin 20 receptor beta
chr6_+_97160749 1.005 NM_022992
Arl6ip5
ADP-ribosylation factor-like 6 interacting protein 5
chr2_-_148558110 1.003 NM_019632
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr2_+_174153230 0.976 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr12_+_110783786 0.936 Meg3
maternally expressed 3
chr19_-_55177562 0.923 Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr8_-_89996089 0.922 Cbln1
cerebellin 1 precursor protein
chr15_-_8660442 0.892 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_+_8915018 0.888 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr3_+_136598485 0.885 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr6_-_84543739 0.885 NM_175475
NM_001177713
Cyp26b1

cytochrome P450, family 26, subfamily b, polypeptide 1

chr15_-_8660729 0.881 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8660462 0.869 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_-_61173753 0.855 NM_201353
Slc6a7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr18_-_43219062 0.850 NM_028392
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_+_37849488 0.846 NM_033575
Pcdhgb2
protocadherin gamma subfamily B, 2
chr15_-_58614642 0.828 Tmem65
transmembrane protein 65
chr18_+_37460452 0.826 NM_053128
Pcdhb3
protocadherin beta 3
chrM_+_67 0.818


chr4_-_132066370 0.816 NM_144907
Sesn2
sestrin 2
chr17_+_25325290 0.816 Unkl
unkempt-like (Drosophila)
chr10_-_126558035 0.811 Os9
amplified in osteosarcoma
chr17_-_35975148 0.800 NM_011655
Tubb5
tubulin, beta 5
chr1_+_81073778 0.798 NM_172849
9430031J16Rik
RIKEN cDNA 9430031J16 gene
chr11_+_31900378 0.789 NM_008741
Nsg2
neuron specific gene family member 2
chr3_-_80606704 0.782 NM_001039195
NM_001083806
NM_013540
Gria2


glutamate receptor, ionotropic, AMPA2 (alpha 2)


chr9_+_86910371 0.776 NM_001037907
Ripply2
ripply2 homolog (zebrafish)
chr18_+_37560490 0.773 NM_053134
Pcdhb9
protocadherin beta 9
chr1_-_67085404 0.763 NM_001190984
NM_001190985
NM_021295
Lancl1


LanC (bacterial lantibiotic synthetase component C)-like 1


chr19_+_27291897 0.759 Vldlr
very low density lipoprotein receptor
chr1_-_157264398 0.755 NM_011273
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr18_-_78402529 0.746 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr8_+_96335202 0.745 Gnao1
guanine nucleotide binding protein, alpha O
chr2_-_73498303 0.738 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr11_-_33103458 0.736 NM_019916
Tlx3
T-cell leukemia, homeobox 3
chr12_+_110800212 0.734 Meg3
maternally expressed 3
chr18_-_33623287 0.732 NM_053078
D0H4S114
DNA segment, human D4S114
chr6_-_13788453 0.730 Gpr85
G protein-coupled receptor 85
chr10_+_59763520 0.716 Psap
prosaposin
chr8_+_46593141 0.708 NM_172752
Sorbs2
sorbin and SH3 domain containing 2
chr11_+_75439670 0.705 Pitpna
phosphatidylinositol transfer protein, alpha
chr2_-_63022140 0.703 NM_133207
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chrX_-_148776674 0.700 Tspyl2
TSPY-like 2
chr18_-_15222079 0.689 NM_001142731
Kctd1
potassium channel tetramerisation domain containing 1
chr9_-_54509453 0.683 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr3_+_89324085 0.679 NM_080466
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr17_+_24607576 0.674 Pgp
phosphoglycolate phosphatase
chr9_-_91260597 0.665 Zic1
zinc finger protein of the cerebellum 1
chrX_+_133357268 0.654 NM_011123
Plp1
proteolipid protein (myelin) 1
chr15_-_8584897 0.649 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_103291963 0.645


chr18_+_37595274 0.640 NM_053137
Pcdhb12
protocadherin beta 12
chr6_+_97160736 0.637 Arl6ip5
ADP-ribosylation factor-like 6 interacting protein 5
chr3_+_98084352 0.633 NM_008256
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chr12_+_53800302 0.629 Akap6
A kinase (PRKA) anchor protein 6
chr8_-_89996474 0.628 NM_019626
Cbln1
cerebellin 1 precursor protein
chr9_-_67680136 0.623 NM_001163143
C2cd4a
C2 calcium-dependent domain containing 4A
chr5_-_124637176 0.619 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr12_+_39506844 0.616 NM_007960
Etv1
ets variant gene 1
chr5_-_137548123 0.614 NM_008871
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
chr13_-_8870975 0.613 NM_001039388
Wdr37
WD repeat domain 37
chr2_+_136581861 0.613 Snap25
synaptosomal-associated protein 25
chr18_+_52927362 0.612 NM_026408
Sncaip
synuclein, alpha interacting protein (synphilin)
chr8_-_70498472 0.602 NM_177698
Psd3
pleckstrin and Sec7 domain containing 3
chr12_+_39510297 0.593 NM_001163154
Etv1
ets variant gene 1
chr4_+_144482722 0.587 NM_001172424
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_108236057 0.583 Sars
seryl-aminoacyl-tRNA synthetase
chr4_+_144483110 0.571 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_+_87394543 0.569 Sept4
septin 4
chr12_+_77182878 0.565 Syne2
synaptic nuclear envelope 2
chr9_-_40153864 0.565 Gramd1b
GRAM domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
10.29 4.31e-06 GO:0031644 regulation of neurological system process
5.93 1.10e-03 GO:0044057 regulation of system process
5.81 1.34e-03 GO:0007267 cell-cell signaling
2.41 1.60e-03 GO:0051234 establishment of localization
2.25 1.86e-03 GO:0051179 localization
31.17 3.59e-03 GO:0051930 regulation of sensory perception of pain
31.17 3.59e-03 GO:0051931 regulation of sensory perception
2.37 3.60e-03 GO:0006810 transport
4.09 1.62e-02 GO:0007154 cell communication
7.68 1.66e-02 GO:0050804 regulation of synaptic transmission
7.12 2.68e-02 GO:0051969 regulation of transmission of nerve impulse
140.24 3.16e-02 GO:0034447 very-low-density lipoprotein particle clearance
17.54 3.69e-02 GO:0050806 positive regulation of synaptic transmission
4.01 4.20e-02 GO:0016192 vesicle-mediated transport
1.48 4.36e-02 GO:0065007 biological regulation
3.41 4.83e-02 GO:0051649 establishment of localization in cell

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.70 5.43e-06 GO:0043005 neuron projection
5.74 4.22e-05 GO:0045202 synapse
2.19 1.45e-04 GO:0005886 plasma membrane
2.15 2.38e-04 GO:0071944 cell periphery
6.54 3.27e-04 GO:0043025 neuronal cell body
6.33 4.40e-04 GO:0044456 synapse part
6.23 5.02e-04 GO:0044297 cell body
3.21 3.48e-03 GO:0042995 cell projection
2.57 4.97e-03 GO:0044459 plasma membrane part
1.52 5.55e-03 GO:0016020 membrane
5.91 6.94e-03 GO:0030425 dendrite
7.85 1.31e-02 GO:0045211 postsynaptic membrane
3.80 1.59e-02 GO:0030054 cell junction
1.57 1.76e-02 GO:0044425 membrane part
5.67 2.63e-02 GO:0030424 axon
70.12 3.74e-02 GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex

Gene overrepresentation in function category:

enrichment p-value GO term description
9.84 1.88e-02 GO:0022834 ligand-gated channel activity
84.15 2.69e-02 GO:0022824 transmitter-gated ion channel activity
84.15 2.69e-02 GO:0022835 transmitter-gated channel activity
13.16 2.92e-02 GO:0005230 extracellular ligand-gated ion channel activity
21.77 4.19e-02 GO:0005200 structural constituent of cytoskeleton